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primeFISH Products Solid Tumor
SOLIDTUMOR

PANEL

17-004 p16 (9p21)

The CDKN2A (cyclin dependent kinase inhibitor 2A) gene, inactivated by homozygous deletions with high frequency
often referred to as pl6 or INK4a/ ARF, is located in the in various human primary tumors such as bladder and
9p21.3 chromosome region. Using alternative first exons renal celi carcinomas, prostate and ovarian adenocar-
and an alternative reading frame, the gene encodes two cinomas, non-small cell lung cancer, sarcoma, glioma,
different tumor suppressor proteins pl61NK4a and pl4ARF, mesotheli oma, and melanoma. Furthermore, deletion
both of which are involved in celi cycle regulation. CDK- of the CDKN2A gene is found in up to 80% of T-cell acute
N2A has been identified as a major susceptibility gene lymphoblastic leukemia cases and is associated with poor
for melanoma. The tumor suppressor gene CDKN2A is prognosis and disease relapse.

DELETION
9p21.3 D9S1749 D9S1752
3' 5'
Gen Tel
9p13.2 CDKN2A
246 kb
NORMAL

WI-728 GCT17B09
Gen Tel

347 kb DELETION

(Not to scale)

References
Wilkinson DG: In Situ Hybridization, A Practical Approach, Oxford University Press
(1992) ISBN 0 19 963327 4. www.diagen.com.tr
Schwarz S, et al. (2008) Cytometry A 73: 305-11.
Quelle DE, et al. (1995) Cell 83: 993-1000.

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