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Prenatal primeFISH Products

PRENATAL

PANEL

17-079 AneuFISH Prenatal ı
Probe Kit 13/21 (green/red) and x/v/18 (green/red/aqua)

it is known that common chromosomal abnormalities as mentol retardation and hearing loss are observed in
and the risk of being affected in humans increase with individuals with this syndrome, which is seen in one in
the maternal age of the child. Chromosome numerical 6,000-8,000 newborns. Trisomy of the 21st chromo some
ab normalities cause different syndromes. is most commonly observed and causes Down syndrome.
Abnormal copy numbers of the X and Y chromosomes
Trisomy 13 causes Patau syndrome and is rare. This can lead to o variety of sexes. Far exam ple, Klinefelter
syndrome, which is seen in ap proximately l in 16,000 (47,XXY), Turner (45,X) and other chromosomal disorders
newborns, causes abnormalities that affect many parts of are syndromes caused by changes in X and/or Y copy
the body, including the heart and spinal cord. Trisomy 18 number. These syndromes have variable incidences and
causes Edwards syndrome. An increase in the incidence clinical manifestations.
of leukemia, especially acute megakaryocytic leukemia
and o high incidence of leukemia, abnormalities such

DYZ3
Yp11.1-q11.1

DXZ1
Xp11.1-q11.1
D13S1195 RH17613
3' 5'
Gen Tel
13q14.2 ITM2B
503 kb

D18Z1
18p11.1-q11.1
SHGC-101404 D21S342
5' 3'
Gen Tel
21q22.13
KCNJ6
714 kb

(Not to scale)
(Not to scale)

www.diagen.com.tr References
Kievits T, et al. (1990) Cytogenet Cell Genet 53: 134-6.
Waye JS, Willard HF (1987) Nucleic Acids Res 15: 7549-69.
Cereda and Carey. Orphanet J Rare Dis 2012; 7:81
http://ghr.nlm.nih.gov/condition/trisomy-13

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