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primeFISH Products Solid Tumor
SOLIDTUMOR

PANEL

17-012 17q12 (Her2/Neu) LS Breakapart

The HER2 (ERBB2) Human Epidermal Growth Factor Receptor (ERBBl), ERBB3 (HER3) and ERBB4 (HER4). it is activated
2 gene, located in chromo some band 17q12, is a member in 20-30% of breast cancers and occurs and proliferates
of the Epidermal Growth Factor (EGF) receptor family and and has been associated with a poor prognosis for the
encodes the 185-190 kDa transmembrane glycoprotein patient. Treatment of patients with amplification using
pl85 that functions asa cellular growth factor receptor. the monoclonal antibody Herceptin® (Trastuzumab)
The pl85 protein is alsa located in the EGFR (epidermal has been shown to be effective by specifically targeting
growth factor receptor) subgroup of the RTK (receptor HER2-overexpressing cells and removing them from the
tyrosine kinase) superfamily, which alsa includes EGFR system, increasing survival.

AMPLIFICATION

D17Z1
(17p11.1-q11.1) NORMAL
17q12-q21.2
HUMUT6435 D17S1246
5' 3'
Gen Tel
ERBB2
AMPLIFICATION
833 kb

(Not to scale)

AMPLIFICA
AMPLIFICATIONTION

References
Brunello E, et al. (2012) Histopathology 60: 482-8.
Wolff AC, et al. (2013) J Clin Oncol 31: 3997-4013. www.diagen.com.tr
Ugocsai et al., Anticancer Res. 2005;25(4):3061-6
López-Guerrero JA et al., Int J Cancer. 2006 Apr 1;118(7):1743-9
Popescu NC, et al. (1989) Genomics 4: 362-6.

info@diagen.com.tr PRODUCT CATALOGUE 47