Page 45 - DIAGEN-EN

primeFISH Products Solid Tumor

SOLIDTUMOR
PANEL

17-242 ALK (2p23) /EML4 (2p21)

Through the use of this probe one can distinguish be- gastric and colorectal cancers. Many different breakpoints
tween EML4-ALK inversions and trans locations, such affecting ALK and EML4 have been identified in these
as ALK-TFG or ALK-KIF5B, that affect ALK but not EML4. inversions. Thus, multiple EML4-ALK transcript variants
lnversions of [inv(2)(p2lp23)] on the short arm of chro- have been identified and all contain the intracellular ki-
mosome 2 have been frequently detected in non-small nase portion of ALK. ALK kinase-targeted thera pies can
celi lung cancer (NSCLC) and can lead to the generation provide a very effective therapeutic strategy in NSCLC
of EML4-ALK fusion transcripts. Several literatures have patients with EML4-ALK rearrangements.
also described EML4-ALK fusion transcripts in breast,

2p23.2-p23.1
2p21

SHGC-100079 RH103820 RH35185 SHGC-145883
3' 5'
Tel Gen
ALK

624 kb 908 kb

SHGC-103503 D2S1482
3' 5'
Tel Cent
EML4
1.7 mb

(Not to scale)

References
Kievits T, et al. (1990) Cytogenet Cell Genet 53: 134-6.
Preusser M, et al. (2013) Lung Cancer 80: 278-83. www.diagen.com.tr
Rodig SJ, et al. (2009) Clin Cancer Res 15: 5216-23.

PRODUCT CATALOGUE 45