Page 50 - DIAGEN

Solid Tumor primeFISH Products

SOLIDTUMOR

PANEL

17-220 NTRK3 (15q25) BREAKAPART

NTRK3 is a receptor tyrosine kinase (TK) for neurotro- thyroid cancer, secretory breast carcinoma, and mammary
phin 3 (NT3) and plays an important role in celi survival analogue secretory carcinoma of the salivary gland. The
and development of the central and peripheral nervous most common rearrangement involving the NTRK3 gene
systems. Transloca tions affecting the NTRK3 gene have is t(12;15) (pl3;q25); Asa result, fusion occurs between the
been reported in many cancer types, including glioblas 5’ part of the ETV6 gene and the 3’ part of the NTRK3 gene.
tomas, Philadelphia chromosome-like acute lymphoblastic This fusion gene encodes a hybrid protein consisting of
leukemia, congenital fibrosarco mas, cellular mesoblastic the TK portion of NTRK3 and the dimerization portion of
nephromas, acute myeloid leukemia, radiation-associated ETV6, resulting in a ligand-independent TK activity.

BREAKAPART

D15S1119 D15S99 SHGC-102137 D15S168E
3' 5'
NORMAL
Gen Tel
NTRK3

494 kb 813 kb

DELETION
15q25.3-q26.1

(Not to scale)

www.diagen.com.tr References
Amatu A, et al. (2016) ESMO Open 1: e000023.
Nagasubramanian R, et al. (2016) Pediatr Blood Cancer 63: 1468-70.
Wang L, et al. (2017) J Mol Diagn 19: 387-96.

50 PRODUCT CATALOGUE info@diagen.com.tr