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primeFISH Products Prenatal
PRENATAL

PANEL

1002-CXY Chr X/Y DC Probe Kit

For cases of chronic myeloid leukemia (CML) in individuals The centromeric X/Y probe can detect abnormal copy
who undergo allogeneic bone marrow transplantation numbers of the X and Y chromosomes. Numerical anom-
from the opposite sex, interphase nuclei and metaphase alies associated with the sex chromosomes can lead to
spreads obtained from bone marrow samples are indi- various conditions. For example, Klinefelter syndrome
cated for additional use in standard cytogenetic analysis (47,XXY), Turner syndrome (45,X), and other chromosomal
to identify and count the X and Y chromosomes using disorders are syndromes caused by changes in the copy
FISH. The centromeric X/Y probe is not designed for use numbers of X and/or Y chromosomes. These syndromes
in subjects who have the same sex for bone marrow have variable incidences and clinical manifestations.
transplantation.

DXZ1
Xp11.1-q11.1

DYZ3
Yp11.1-q11.1

(Not to scale)

References

Bryndorf et al. (1996) Am J Hum Genet 59:918-926
Tepperberg et al. (2001) Prenat Diagn 21:293-301 www.diagen.com.tr
Tsuchiya KD. (2011) Clin Lab Med. 31(4):525-42.
Rickman L, et al. (2006) J Med Genet 43:353-361.

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