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primeFISH Products Solid Tumor
SOLIDTUMOR

PANEL

17-219 NTRK2 (9q21) BREAKAPART

NTRK2 (neurotrophic receptor tyrosine kinase 2; also anci neck squamous celi carcinoma, anci lung acienocarci
known as TRKB) is a receptor tyrosine kinase (TK) that noma. NTRK2 rearrangements result in fusion of the 3’
phosphorylates itself anci members of the MAPK pathway enci of the NTRK2 gene with the 5’ enci of an activating
after binciing of brain-cie riveci growth factor (BDGF) anci partner gene. More than 20 ciifferent fusion partners
neurotrophin 4/5 (NT-4/5).. it plays an important role in of NTRK2 have been icientifieci. AII these fusion genes
the cievelopment of the central anci peripheral nervous encocie hybrici proteins containing the TK portion of
systems anci celi survival. Translocations affecting the NTRK2 anci the N terminus of partner proteins encociing
NTRK2 gene have been reporteci in several types of cancer, the ciimerization portions, resulting in liganci-inciepen
incluciing glioblasto mas, pilocytic astrocytomas, heaci cient TK activity.

BREAKAPART

WI-9204 SHGC-142742 D9S201 RH25851
5' 3'
Gen Tel
NTRK2 NORMAL
808 kb 501 kb

9q21.32-q21.33

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References
Cocco E, et al. (2018) Nat Rev Clin Oncol 15: 731-47.
Hsiao SJ, et al. (2019) J Mol Diagn 21: 553-71. www.diagen.com.tr
Raez LE & Rolfo C (2016) Lung Cancer Manag 5: 1-4.
Wu G, et al. (2014) Nat Genet 46: 444-50.

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