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P. 48
Solid Tumor primeFISH Products
SOLIDTUMOR
PANEL
17-218 NTRK1 (1q23) BREAKAPART
The neurotrophic tyrosine receptor kinase genes (NTRKl, end of various activating genes occurs. He has identified
NTRK2, and NTRK3) encode o family of receptor tyrosine over 40 5’ gene part ners for NTRKl in o wide variety of
kinases that play important roles in celi survival, prolifer- human tumor types, including papillary thyroid carcinoma
ation, and cellular differentiation in healthy human cells. (PTC), lung cancer, sarcomas, and spitzoid neoplasms.
NTRK gene rearrangements have been found to occur NTRKl rearrangements have been shown to be involved
in very different tumor types. Fusion of the 3’ end of the in thyroid carcinogenesis.
NTRK gene encoding the NTRK kinase region and the 5’
BREAKAPART
RH0443 SHGC-15794 SHGC-153051 RH45945
5' 3'
Cent Tel
NTRK1
535 kb 476 kb NORMAL
1q22-q23.1
RE-ARRANGEMENT
(Not to scale)
www.diagen.com.tr References
Hsiao SJ, et al. (2019) J Mol Diagn 21: 553-71.
Marchiò C, et al. (2019) Ann Oncol 30: 1417-27.
Wilkinson DG: In Situ Hybridization, A Practical Approach, Oxford University Press (1992) ISBN
0 19 963327 4.
Vaishnavi A, et al. (2013) Nat Med 19: 1469-72.
48 PRODUCT CATALOGUE
