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HEMATOLOGY

PANEL

17-010 ATM (11q22)

The ATM gene is located in the 11q22.3 band region and the 11q22.3 region. Analyzing CLL cases using traditional
encodes a protein kinase. The encoded kinase regulates banding techniques is challenging due to the low mitotic
responses to DNA double-strand breaks by triggering index of neoplastic cells. The introduction of fluorescence
pathways that synchronize DNA repair and apoptosis in situ hybridization (FISH) for interphase cytogenetics has
during the cell cycle. Approximately 20% of Chronic Lym- greatly enhanced the sensitivity of cytogenetic analysis.
phocytic Leukemia (CLL) cases exhibit ATM deletions in

DELETION

D11Z1
(11p11.1-q11.1) NORMAL
D11S4485 RH39918
5' 3'
Gen Tel
ATM
312 kb DELETION
11q22.3

(Not to scale)

References
www.diagen.com.tr Doehner et al (1997) Blood 89:2516-2522

Tsimberidou et al (2009) Cancer 115:373-380
Stankovic T & Skowronska A (2014) Leuk Lymphoma 55: 1227-39.
Zenz T, et al. (2010) Best Pract Res Clin Haematol 23: 71-84.
Wilkinson DG: In Situ Hybridization, A Practical Approach, Oxford University Press (1992) ISBN 0 19 963327 4.

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