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primeFISH Products Hermatology
HEMATOLOGY
PANEL
17-142 PDGFRB (5q32) Breakapart
The PDGFRB (Platelet-Derived Growth Factor Receptor in myelodysplastic/myeloproliferative neoplasms (MDS/
Beta) gene, located at 5q32-q33.1, encodes a transmem- MPNs), chronic myeloproliferative disorders (CMPDs), acute
brane glycoprotein from the type III receptor tyrosine myeloid leukemia (AML), and atypical (BCR-ABL1-nega-
kinase family and plays an important role in various tive) chronic myeloid leukemia/chronic myelomonocytic
cellular processes. Translocations involving the PDGFRB leukemia (CML/CMML)-like diseases, often accompanied
gene are rare genetic disorders and are typically found by eosinophilia and splenomegaly.
BREAKAPART
NORMAL
SHGC-145955 D5S1708 SHGC-85368 D5S519
3' 5'
Gen Tel
PDGFRB
348 kb 352 kb DELETION
5q32-q33.1
(Not to scale)
References
www.diagen.com.tr
Vega F, et al. (2015) Am J Clin Pathol 144: 377-92.
Savage N, et al. (2013) Int J Lab Hematol 35: 491-500.
Kievits T, et al. (1990) Cytogenet Cell Genet 53: 134-6.
info@diagen.com.tr PRODUCT CATALOGUE 35
