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primeFISH Products Hematology

HEMATOLOGY
PANEL

17-183 IGH-cMYC t(8;14)

The MYC proto-oncogene (MYC proto-oncogene, bHLH translocation involving the MYC gene region is t(8;14)
transcription factor) encodes a transcription factor that (q24.21;q32.3), which can be found in approximately
is essential for cell growth and proliferation, and it exten- 80% of Burkitt lymphoma cases, relocating the MYC gene
sively participates in tumorigenesis. In Burkitt lymphoma, next to the IgH (immunoglobulin heavy chain) locus.
c-MYC/IGH translocation involving t(8;14)(q24;q32) and Other translocations affecting the MYC gene are t(8;22)
its variant forms t(2;8)(p13;q24) and t(8;22)(q24;q11) are (q24.21;q11.2) and t(2;8)(p11.2;q24.21), both of which
observed, occurring in mature B cells or Burkitt-type involve one of the two immunoglobulin light chain loci.
Acute Lymphoblastic Leukemia (ALL). The most common

TRI-COLOR TRANSLOCATION

RH48719 SHGC-19178
5' 3'
Cent Tel
D8Z2 MYC NORMAL
(8p11.1-q11.1) 1.1 mb

RH98285 SHGC-106213
3' 5'
Cent Tel
IGH TRANSLOCATION
1.5 mb

8q24.21

14q12.33 Chr.8 Monosomy

Not to scale)

References

May P, et al. (2010) Cancer Genet Cytogenet 198: 71-5.
Veronese ML, et al. (1995) Blood 85: 2132-8.
Shou et al., PNAS 2000;97(1):228-33 www.diagen.com.tr
Hoffman, Ronald (2009). Hematology : basic principles and practice (5th ed. ed.). Philadelphia, PA:
Churchill Livingstone/Elsevier. pp. 1304–1305

PRODUCT CATALOGUE 39