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Hematology primeFISH Products

HEMATOLOGY
PANEL

17-064 ATM / TP53

The tumor suppressor TP53 gene located in the 17p13.1 in CLL patients is associated with failure of treatment
region and the protein kinase ATM gene located in the with alkylating agents and shorter survival times. The
11q22.3 region are frequently deleted in cases of chronic ATM (ataxia telangiectasia mutated) gene is located at
lymphocytic leukemia (CLL). TP53 (tumor protein 53; also 11q22.3 and encodes a protein kinase involved in cell
known as p53) gene deletions have been detected in CLL, cycle regulation, including TP53 activation. CLL patients
multiple myeloma (MM), and acute myeloid leukemia (AML) with 11q deletion exhibit rapid disease progression and
patients. Allelic loss of the short arm of chromosome 17 lower overall survival rates.

DELETION

17p13.1
D17S1783 RH67972
3' 5'
Tel Cent
TP53

409 kb
NORMAL ATM DELETION

D11S4485 RH39918
5' 3'
Cent Tel
ATM
TP53 DELETION TP53/ATM DELETION
312 kb

11q22.3

(Not to scale)

References
www.diagen.com.tr Dal Bo M, et al. (2011) Genes Chromosomes Cancer 50: 633-43.

Ripollés L, et al. (2006) Cancer Genet Cytogenet 171: 57-64.
Stankovic et al., Blood 2004;103(1):291-300
Baliakas P, et al., Leukemia. 2014;(April):1-8
Stilgenbauer et al (2002) Leukemia 16:993-1007

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