Page 33 - DIAGEN
P. 33
primeFISH Products Hermatology
HEMATOLOGY
PANEL
17-044 RARA (17q21) Breakapart
RARA gene has been found to have various fusion part- on chromosome 17q21.2. In the majority of APL cases,
ners, but in approximately 95% of acute promyelocytic the fusion occurs between the RARA gene and the PML
leukemia (APL) cases, rearrangements involving the PML gene. However, in less than 5% of APL cases, the RARA
gene on 15q24.1 are detected. The RARA gene is located gene is involved in fusion with different fusion partners.
BREAKAPART
17q21.1-q21.2 NORMAL
RH125559 RH80710 RH54983 SHGC-83863
3' 5'
Gen Tel
RARA
452 kb 169 kb DELETION
(Not to scale)
References
Brockmann SR, et al. (2003) Cancer Genet and Cytogenet 145:144-51.
Sanz MA, et al. (2009) Blood 113: 1875-91. www.diagen.com.tr
Kievits T, et al. (1990) Cytogenet Cell Genet 53: 134-6.
Tomita et al., International Journal of Haematology 2013;97(6):717-725
Zhang et al., Blood Reviews 2015;29(2):101-125
info@diagen.com.tr PRODUCT CATALOGUE 33
