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primeFISH Products Hematology

HEMATOLOGY
PANEL

17-001-B del (13q14) (D13S319) / LAMP1 (13q34)

Deletions involving the 13q14 region are frequently ob- prognostic relevance may be linked to other concurrent
served in a wide range of hematological disorders. Chro- genetic lesions. Deletions on the long arm of chromosome
mosome 13q deletions occur in 16% to 40% of multiple 13 are also frequently detected in aggressive non-Hodgkin
myeloma (MM) cases, with the majority being complete lymphoma (NHL) patients. Therefore, when combined
monosomy 13 (85%), while the remaining 15% represent with other biological markers, morphology, and clinical
deletions of 13q14. A case study in multiple myeloma information, fluorescence in situ hybridization (FISH) is a
patients has narrowed down the critical deleted region to valuable tool for predicting disease progression and overall
13q14. Historically, 13q deletions have been associated survival in chronic lymphocytic leukemia (CLL) patients.
with poor prognosis in MM, but it is now believed that its

DELETION

D13S319 D13S1556
3' 5'
Gen Tel
DLEU2
13q14.2 405 kb
NORMAL

SHGC-110591 RH17637
5' 3'
Gen Tel
LAMP1
576 kb DELETION
13q34

(Not to scale)

References

Ouillette P, et al. (2011) Clin Cancer Res 21: 6778-90.
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New
Jersey: John Wiley & Sons Inc. www.diagen.com.tr
Nelson et al (2007) Am J Clin Pathol 128:323-332
Doehner et al (2000) N Engl J Med 343:1910-1916

PRODUCT CATALOGUE 37