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Hermatology primeFISH Products

HEMATOLOGY

PANEL

17-042 ABL1 Breakapart

ABL1 gene rearrangements involving various fusion partners ALL, also known as Philadelphia chromosome (Ph)-like
occur in various hematological malignancies, resulting in ALL, is found in approximately 10-20% of pediatric cas-
fusion of the ABL1 gene. The t(9;22)(q34.1;q11.2) trans- es and 20-30% of all adult B-cell precursor ALL cases.
location leads to the formation of the BCR/ABL1 fusion, BCR-ABL1-like ALL is characterized by a gene expression
which is observed in approximately 90% of patients with profile that significantly overlaps with Ph-positive (Ph+)
chronic myeloid leukemia (CML) and approximately 25% ALL. Unlike Ph+ ALL, which is defined by the presence
of adults with acute lymphoblastic leukemia (ALL). In of the BCR-ABL1 fusion resulting from t(9;22)(q34;q11),
2017, the World Health Organization (WHO) recognized BCR-ABL1-like cases involve various genomic alterations
BCR-ABL1-like ALL as a distinct entity within the subtype that enhance kinase and cytokine receptor signaling.
of B-lymphoblastic leukemia/lymphoma. BCR-ABL1-like

BREAKAPART

NORMAL
SHGC-154599 D9S120 SHGC-147320 D9S1991
5' 3'
Gen Tel
ABL1
763 kb 682 kb
DELETION

9q34.11-34.13

(Not to scale)

www.diagen.com.tr References
Tasian et al (2017) Blood 130:2064-2072
De Braekeleer E, et al. (2011) Eur J Haematol 86: 361-71.
Zheng X, et al. (2009) PLoS One 4: e7661.
Graux C, et al. (2009) Leukemia 23: 125-33.
Rieder H, et al. (1998) Leukemia 12: 1473-81.
Jain and Abraham (2019) Arch Pathol Lab Med:doi:10.5858/arpa.2019-0194-RA

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