Page 27 - DIAGEN-EN

primeFISH Products Hematology

HEMATOLOGY
PANEL

17-009 AFF1-MLL t(4;11)

Translocations involving the KMT2A gene are detected in KMT2A gene. The most common translocation involving
approximately 5-6% of all acute myeloid leukemias (AML) the KMT2A gene in acute lymphoblastic leukemia (ALL) is
and 5-10% of all acute lymphoblastic leukemias (ALL). The the t(4;11)(q21;q23.3), which involves the KMT2A (lysine
frequency of translocations involving the KMT2A gene is methyltransferase 2A) gene located at 11q23.3 and the
significantly higher in infants with AML (50%) and ALL (80%). AFF1 (AF4/FMR2 family member 1) gene located at 4q21.3.
Over 30 fusion partners have been documented for the

TRANSLOCATION

SHGC-50681 RH59180
3' 5'
Cent Tel
AFF1
854 kb

4q21.2-q22.1 WI-9069 D11S797 NORMAL
5' 3'
Cent Tel
KMT2A

485 kb
TRANSLOCATION

11q23.3

(Not to scale)

References
De Braekeleer M, et al. (2005) Anticancer Res 25: 1931-44.
Ford DJ & Dingwall AK (2015) Cancer Genet 208(5): 178-91. www.diagen.com.tr
Keefe JG, et al. (2010) J Mol Diagn 12: 441-52.
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New
Jersey: John Wiley & Sons Inc.
Kumar et al., Leuk Res. 2011;35(3):305-9

PRODUCT CATALOGUE 27