Page 23 - DIAGEN-EN

primeFISH Products Hematology

HEMATOLOGY
PANEL

17-011 IGH-MAF t(14;16)

The MAF (MAF bZIP transcription factor) gene is located in The t(14;16)(q32.3;q23) translocation is frequently
the IGH (immunoglobin heavy locus) at 16q23 and 14q32.3. found in multiple myeloma (MM). MM is a malignant
Approximately 50-60% of multiple myeloma (MM) cases post-germinal center tumor of somatic-mutated,
involve translocations involving IGH and one of several isotype-transformed plasma cells that accumulate in
partners such as CCND1, NSD2 (WHSCl) and FGFR3, the bone marrow.
CCND3, MAF or MAFB. The t(14; 16) (q32.3; q23)
translocation is a recurrent translocation seen in 2-10%
of MM.

TRANSLOCATION

SHGC-3168 D16S289
5' 3'
Cent Tel
WWOX
1.2 mb

RH98285 SHGC-106213 NORMAL
3' 5'
Cent Tel
IGH
16q23.1-q23.2 1.5 mb
TRANSLOCATION

14q32.33

(Not to scale)

References
Fonseca et al., Leukemia 2009;23(12):2210-2221
Mascarello JT, Hirsch B, Kearney HM, et al. Section E9 of the American College of Medical Genetics tech- www.diagen.com.tr
nical standards and guidelines: fluorescence in situ hybridization. Genet Med. 2011;13(7):667-675.
Chesi M, et al. (1998) Blood 91: 4457-63.
Fonseca R, et al. (2009) Leukemia 23: 2210-21.

PRODUCT CATALOGUE 23