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primeFISH Products Hermatology
HEMATOLOGY

PANEL

17-011 IGH-MAF t(14;16)

The MAF (MAF bZIP transcription factor) gene is located in recurrent translocation seen in 2-10% of MM. The t(l4;16)
the IGH (immunoglobin heavy locus) at 16q23 and 14q32.3. (q32.3;q23) translocation is frequently found in multiple
Approximately 50-60% of multiple myeloma (MM) cases myeloma (MM). MM is a malignant post-germinal center
involve translocations involving IGH and one of several tumor of somatic-mutated, isotype-transformed plasma
partners such as CCNDl, NSD2 (WHSCl) and FGFR3, CCND3, cells that accu mulate in the bone marrow.
MAF or MAFB. The t(l4; 16) (q32.3; q23) translocation is a

SHGC-3168 D16S289 TRANSLOCATION
5' 3'
Gen Tel
WWOX

1.2 mb

NORMAL

RH98285 SHGC-106213
3' 5'
Gen Tel TRANSLOCATION
16q23.1-q23.2
IGH
14q12.33
1.5 mb
(Not to scale)

TRANSLOCATION

References
Fonseca et al., Leukemia 2009;23(12):2210-2221
Mascarello JT, Hirsch B, Kearney HM, et al. Section E9 of the American College of Medical Genetics tech- www.diagen.com.tr
nical standards and guidelines: fluorescence in situ hybridization. Genet Med. 2011;13(7):667-675.
Chesi M, et al. (1998) Blood 91: 4457-63.
Fonseca R, et al. (2009) Leukemia 23: 2210-21.

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