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Hermatology primeFISH Products

HEMATOLOGY

PANEL

17-073 IGH (14q32) Breakapart

Rearrangements involving the IGH (immunoglobulin heavy lymphoma (MCL), 80% of t(l4;18)(q32.3;q2l.3) follicular lym
chain) gene are considered to be cytogenetic markers of phoma (FL) in , t(3;14)(q27;q32.3) is found in diffuse large
non-Hodgkin lymphoma (NHL). NHLs represent 50% of all B-cell lymphoma (DLBCL) and t(8;14)(q24.2l;q32.3) Burkitt’s
hematologi cal malignancies. IGH gene rearrangements lymphoma. in all of these translocations, an oncogene
have been identified in approximately 50% of NHLs and are located near the breakpoint of the translocation partner is
associated with specific subtypes of NHLs. Translocation activated by passing near the IGH regula tory sequences.
of t(ll;l4)(ql3.3;q32.3) in approximately 95% of mantle celi

BREAKAPART

NORMAL
RH48502 SHGV-148425 RH69050 SHGC-85227
3' 5' 3' 5'
Gen Tel
JAG2 Variable Segment

612 kb 577 kb
DELETION
14q32.32

(Not to scale)

www.diagen.com.tr References
Hehne S, et al. (2012) Pathol Res Pract 208: 510-7.
Lu S, et al. (2004) Cancer Genet and Cytogenet 152: 141-5.
Bernicot et al., Cytogenet Genome Res. 2007;118(2-4):345-52
Nguyen et al (2017) Genes 8:1-23

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