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Hematology primeFISH Products

HEMATOLOGY
PANEL

17-073 IGH (14q32) Breakapart

Rearrangements involving the IGH (immunoglobulin heavy lymphoma (MCL), 80% of t(14;18)(q32.3;q21.3) follicular
chain) gene are considered to be cytogenetic markers of lymphoma (FL) in , t(3;14)(q27;q32.3) is found in diffuse
non-Hodgkin lymphoma (NHL). NHLs represent 50% of all large B-cell lymphoma (DLBCL) and t(8;14)(q24.21;q32.3)
hematological malignancies. IGH gene rearrangements Burkitt’s lymphoma. In all of these translocations, an
have been identified in approximately 50% of NHLs and oncogene located near the breakpoint of the
are associated with specific subtypes of NHLs. translocation partner is activated by passing near the IGH
Translocation of t(11;14)(q13.3;q32.3) in approximately regula tory sequences.
95% of mantle cell

BREAKAPART

NORMAL
RH48502 SHGV-148425 RH69050 SHGC-85227
3' 5' 3' 5'
Cent Tel
JAG2 IGH

612 kb 577 kb
RE-ARRANGEMENT
14q32.33

(Not to scale)

www.diagen.com.tr References
Hehne S, et al. (2012) Pathol Res Pract 208: 510-7.
Lu S, et al. (2004) Cancer Genet and Cytogenet 152: 141-5.
Bernicot et al., Cytogenet Genome Res. 2007;118(2-4):345-52
Nguyen et al (2017) Genes 8:1-23

18 PRODUCT CATALOGUE