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HEMATOLOGY

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17-077 IGH-CCNDl t(11;14)

The translocation moves the CCNDl gene (also known as The t(ll;l4)(ql3.3;q32.3) translocation containing the
cyclin Dl; PRADl and BCLl) near the IGH (immunoglobu- CCNDl and IGH gene regions is detected in up to 95% of
lin heavy locus, also known as IGH®) locus, resulting in patients with mantle cell lymphomas (MCL) and is the
constitutive overexpression of CCNDl. The t(ll;l4)(ql3;q32) genetic variant of this subtype of low-grade peripheral
rearrangement involving CCNDl and IGH is considered B-cell neoplasms considered to be an indicator. However,
indicative of mantle celi lymphoma (MHL), whose presence t(ll;l4) has also been detected in other lymphoprolifera-
can be used to aid in the differential diagnosis of CD5+ tive disorders (LPDs) such as B-prolymphocytic leukemia
B-cell lymphoproliferative diseases. (PLL) and less frequently in plasma celi myelomas, B-cell
chronic lymphocytic leukemia, and villous lymphocyte
splenic lymphomas (SLVL).

TRANSLOCATION
RH7576 D11S2927
5' 3'
Gen Tel
CCND1
1.1 mb
NORMAL
11q13.3

RH98285 SHGC-106213
3' 5'
TRANSLOCATION
Gen Tel
IGH
1.5 mb
14q12.33

(Not to scale) TRANSLOCATION

References
Bentz JS, et al. (2004) Cancer 102: 124-31.
Li JY, et al. (1999) Am J Pathol 154: 1449-52. www.diagen.com.tr
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New
Jersey: John Wiley & Sons Inc.

info@diagen.com.tr PRODUCT CATALOGUE 21