Page 21 - DIAGEN-EN

primeFISH Products Hematology

HEMATOLOGY
PANEL

17-077 IGH-CCNDl t(11;14)

The translocation moves the CCNDl gene (also known as The t(11;14)(q13.3;q32.3) translocation containing
cyclin D1; PRAD1 and BCL1) near the IGH the CCND1 and IGH gene regions is detected in up to
(immunoglobulin heavy locus, also known as IGH) 95% of patients with mantle cell lymphomas (MCL)
locus, resulting in constitutive overexpression of and is the genetic variant of this subtype of low-grade
CCND1.The t(11;14)(q13;q32) rearrangement involving peripheral B-cell neoplasms considered to be an
CCND1 and IGH is considered indicative of mantle cell indicator. However, t(11;14) has also been detected in
lymphoma (MHL), whose presence can be used to aid in other lymphoproliferative disorders (LPDs) such as
the differential diagnosis of CD5+ B-cell B-prolymphocytic leukemia (PLL) and less frequently in
lymphoproliferative diseases. plasma celi myelomas, B-cell chronic lymphocytic
leukemia, and villous lymphocyte splenic lymphomas
(SLVL).

TRANSLOCATION

RH7576 D11S2927
5' 3'
Cent Tel
CCND1

1.1 mb NORMAL
11q13.3
RH98285 SHGC-106213
3' 5'
Cent Tel
IGH
TRANSLOCATION
1.5 mb

14q32.33

(Not to scale)

References
Bentz JS, et al. (2004) Cancer 102: 124-31.
Li JY, et al. (1999) Am J Pathol 154: 1449-52. www.diagen.com.tr
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New
Jersey: John Wiley & Sons Inc.

PRODUCT CATALOGUE 21