Page 17 - DIAGEN-EN

primeFISH Products Hematology

HEMATOLOGY
PANEL

17-066 c-MYC (8q24) Breakapart

The MYC proto-oncogene (MYC proto-oncogene, bHLH lymphoma types. MYC rearrangements that activate MYC
transcription factor, a.k.a. CMYC) encodes a transcription by translocation with one of the three immunoglobulin
factor required tor cell growth and proliferation and is loci (IGH, IGL, or IGK) are detected in nearly all cases of
extensively involved in tumorigenesis. Translocations Burkitt lymphoma at diagnosis. They are also seen in
involving the MYC gene are thought to be the cyto genetic diffuse large B-cell lymphoma (DLBCL), multiple myeloma,
hallmark of Burkitt’s lymphoma, but are also found in other and plasmablastic lymphoma, among other diseases.

BREAKAPART

SHGC-130556 SHGC-141909 SHGC-2893 D8S321
5' 3'
Cent Tel
MYC
NORMAL
442 kb 527 kb

RE-ARRANGEMENT

8q24.21
(Not to scale)

References
Elyamany G, et al., Adv Hematol 2015;2015:315289
Mascarello JT, Hirsch B, Kearney HM, et al. Section E9 of the American College of Medical Genetics tech- www.diagen.com.tr
nical standards and guidelines: fluorescence in situ hybridization. Genet Med. 2011;13(7):667-675.
Haralambieva E, et al. (2004) Genes Chromosomes Cancer 40: 10-8.
Veronese ML, et al. (1995) Blood 85: 2132-8.

PRODUCT CATALOGUE 17