Page 20 - DIAGEN

Hermatology primeFISH Products

HEMATOLOGY

PANEL

17-074 IGH-cMYC t(B;14)

MYC proto-oncogene (MYC proto-oncogene, bHLH tran- also observed.The most common translocation t(8;14)
scription factor) encodes a transcrip tion factor required (q24.2l;q32.3) involving the MYC gene region can be found
for celi growth and proliferation and is extensively involved in approximately 80% of Burkitt lymphoma cases and
in tumorigene sis. Burkitt lymphoma has the cMYC/IGH moves the MYC gene near the lgH (immunoglobulin heavy
translocation, t(8;14)(q24;q32) and variant forms t(2;8) chain) locus. Other translocations affecting the MYC gene
(pl3;q24) and t(8;22)(q24;qll) and is a mature B celi or are t(8;22)(q24.2l;qll.2) and t(2;8)(pll.2;q24.21), both of
Burkitt type Acute Lymphoblastic Leukemia (ALL) is which involve one of two immunoglobulin light chain loci.

TRANSLOCATION
RH48719 SHGC-19178
5' 3'
Gen Tel
MYC
1.1 mb
NORMAL

RH98285 SHGC-106213
3' 5'
TRANSLOCATION
Gen Tel
IGH
8q24.21
1.5 mb
14q12.33
TRANSLOCATION
(Not to scale)

www.diagen.com.tr References
May P, et al. (2010) Cancer Genet Cytogenet 198: 71-5.
Veronese ML, et al. (1995) Blood 85: 2132-8.
Shou et al., PNAS 2000;97(1):228-33
Hoffman, Ronald (2009). Hematology : basic principles and practice (5th ed. ed.). Philadelphia, PA: Churchill Livingstone/Elsevier. pp.
1304–1305

20 PRODUCT CATALOGUE info@diagen.com.tr