Page 20 - DIAGEN-EN

Hematology primeFISH Products

HEMATOLOGY
PANEL

17-074 IGH-cMYC t(8;14)

MYC proto-oncogene (MYC proto-oncogene, bHLH tran- The most common translocation t(8;14)(q24.21;q32.3)
scription factor) encodes a transcrip tion factor required involving the MYC gene region can be found in
for celi growth and proliferation and is extensively involved approximately 80% of Burkitt lymphoma cases and
in tumorigenesis. Burkitt lymphoma has the cMYC/IGH moves the MYC gene near the lgH (immunoglobulin heavy
translocation, t(8;14)(q24;q32) and variant forms t(2;8) chain) locus. Other translocations affecting the MYC
(p13;q24) and t(8;22)(q24;q11) and is a mature B cell gene are t(8;22)(q24.21;q11.2) and t(2;8)
or Burkitt type Acute Lymphoblastic Leukemia (p11.2;q24.21), both of which involve one of two
(ALL) is also observed. immunoglobulin light chain loci.

TRANSLOCATION

RH48719 SHGC-19178
5' 3'
Cent Tel
MYC

1.1 mb
NORMAL

RH98285 SHGC-106213
3' 5'
Cent Tel
IGH TRANSLOCATION

1.5 mb
8q24.21
14q32.33

(Not to scale)

www.diagen.com.tr References
May P, et al. (2010) Cancer Genet Cytogenet 198: 71-5.
Veronese ML, et al. (1995) Blood 85: 2132-8.
Shou et al., PNAS 2000;97(1):228-33
Hoffman, Ronald (2009). Hematology : basic principles and practice (5th ed. ed.). Philadelphia, PA: Churchill Livingstone/Elsevier. pp.
1304–1305

20 PRODUCT CATALOGUE