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HEMATOLOGY

PANEL

17-086 IGH-MAFB t(14;20)

The t(l4;20)(q32.3;ql2) translocation is frequently found in were detected in 40% of MGUS and MM tumors. These
multiple myeloma (MM). MM is a low-grade proliferative, are t(ll;l4)(ql3.3;q32.3), t(6;14)(p2l.l;q32.3), t, which contain
malignant postgerminal center tumor of somatic-mutat- the CCNDl, CCND3, FGFR3 and NSD2, MAF, and MAFB
ed, isotope-converted plasma cells that accumulate in genes, respectively. (4;14)(pl6.3;q32.3), t(l4;16)(q32.3;q23),
the bone marrow. it is usually preceded by a premaline and t(l4;20)(q32.3;ql2) translocations. t(l4;20) occurs in
stage known as mono clonal gammopathy of unknown approximately 1-2% of MM patients and is associated
significance (MGUS). Five recurrent primary translocations with an unfavorable prognosis.
involving the immunoglobulin heavy chain (IGH) locus

TRANSLOCATION
SHGC-78973 STSG2366
3' 5'
Gen Tel
MAFB
1.4 mb

NORMAL

RH98285 SHGC-106213
3' 5'
Gen Tel
20q12 IGH
TRANSLOCATION
1.5 mb
14q12.33

(Not to scale)
TRANSLOCATION

References
Fonseca et al., Leukemia 2009;23(12):2210-2221
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New www.diagen.com.tr
Jersey: John Wiley & Sons Inc.
Chesi M, et al. (1998) Blood 92: 4457-63.
Hanamura I, et al. (2001) Jpn N Cancer Res 92: 638-44.

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