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primeFISH Products Hematology

HEMATOLOGY
PANEL

17-086 IGH-MAFB t(14;20)

The t(14;20)(q32.33;q12) translocation is frequently were detected in 40% of MGUS and MM tumors. These
found in multiple myeloma (MM). MM is a low-grade are t(11;14)(q33;q32.3), t(6;14)(p2l.l;q32.3), which contain
proliferative, malignant postgerminal center tumor of the CCND1, CCND3, FGFR3 and NSD2, MAF, and
somatic-mutated, isotope-converted plasma cells that MAFB genes, respectively. (4;14)(p16.3;q32.33), t(14;16)
accumulate in the bone marrow. it is usually preceded (q32.33;q23), and t(14;20)(q32.33;q12) translocations.
by a premaline stage known as mono clonal t(14;20) occurs in approximately 1-2% of MM patients
gammopathy of unknown significance (MGUS). Five and is associated with an unfavorable prognosis.
recurrent primary translocations involving the
immunoglobulin heavy chain (IGH) locus

TRANSLOCATION

SHGC-78973 STSG2366
3' 5'
Cent Tel
MAFB
1.4 mb

20q12
NORMAL
RH98285 SHGC-106213
3' 5'
Cent Tel
IGH
1.5 mb
14q32.33 TRANSLOCATION

(Not to scale)

References
Fonseca et al., Leukemia 2009;23(12):2210-2221
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New www.diagen.com.tr
Jersey: John Wiley & Sons Inc.
Chesi M, et al. (1998) Blood 92: 4457-63.
Hanamura I, et al. (2001) Jpn N Cancer Res 92: 638-44.

PRODUCT CATALOGUE 25