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Hermatology primeFISH Products

HEMATOLOGY

PANEL

17-005 MYB (6q23)

The MYB (MYB proto-oncogene, transcription factor) gene found in different types of lymphoid neoplasms. Several
primarily codes for a transcription factor expressed in major deletion regions have been identified in the long
immature lymphoid and myeloid T-cells. The long arm of arm of chromosome 6, with 6q23 being one of them. It
chromosome 6 (6q) is frequently associated with chromo- has been shown that 3-10% of chronic lymphocytic leu-
somal abnormalities observed in various types of cancer, kemia (CLL) cases carry structural abnormalities in the
including hematological malignancies. 6q abnormalities 6q chromosome region.
are among the most common chromosomal changes

DELETION
9q21.3

SHGC-155125 SHGC-106080
3' 5'
Gen Tel
MLLT3 NORMAL
811 kb

WI-9069 D11S797
5' 3'
Gen Tel DELETION
KMT2A

485 kb

11q23.3
(Not to scale)

www.diagen.com.tr References
Van Vlierberghe and Ferrando, J of Clin Inv 2012;122(10):3398-3406
Mascarello JT, Hirsch B, Kearney HM, et al. Section E9 of the American College of Medical Genetics technical standards and guidelines:
fluorescence in situ hybridization. Genet Med. 2011;13(7):667-675.
Döhner H, et al. (1999) J Mol Med 77: 266-81.
Wang DM, et al. (2011) Leuk Lymphoma 52: 230-7.

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