Page 24 - DIAGEN-EN

Hematology primeFISH Products

HEMATOLOGY
PANEL

17-058 IGH-BCL2 t(14;18)

Translocations involving the BCL2 (B-cell lymphoma 2) gene and in 20-30% of diffuse large B-cell lym phoma (YBBCL)
and the IGH (immunoglobulin heavy locus, also known cases. As a result of the rearrangement, the BCL2
as IGH) gene are considered cytogenetic markers of gene at 18q21.33 is moved next to the IGH
follicular lymphoma (FL). FL is one of the most common (immunoglobulin heavy chain) locus at 14q32.33,
non-Hodgkin lymphomas (NHL). IGH-BCL2 rearrangements leading to overexpression of the anti-apoptotic protein
are observed in 70-95% of follicular lymphoma (FL) cases BCL2.

TRANSLOCATION

SHGC-104619 STSG619400
5' 3'
Cent Tel
BCL2

1.3 mb

NORMAL
RH98285 SHGC-106213
3' 5'
Cent Tel
IGH
14q32.33
18q21.33 1.5 mb
TRANSLOCATION

(Not to scale)

www.diagen.com.tr References
Baró C, et al. (2011) Leuk Res 35: 256-9.
Da Cunha Santos G, et al. (2011) Cancer Cytopathol 119: 254-62.
Nguyen-Khac F, et al. (2011) Am J Blood Res 1: 13-21.
Bassegio L et al., Br J Haematol 2012;158(4):489-98

24 PRODUCT CATALOGUE