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HEMATOLOGY

PANEL

17-058 IGH-BCL2 t(14;18)

Translocations involving the BCL2 (B-cell lymphoma 2) gene and in 20-30% of diffuse large B-cell lym phoma (YBBCL)
and the IGH (immunoglobulin heavy locus, also known cases. As a result of the rearrangement, the BCL2 gene
as IGH®) gene are considered cytogenetic markers of at l8q2l.33 is moved next to the IGH (immunoglobulin
follicular lymphoma (FL). FL is one of the most common heavy chain) locus at l4q32.33, leading to overexpression
non-Hodgkin lymphomas (NHL). IGH-BCL2 rearrangements of the anti-apoptotic protein BCL2.
are observed in 70-95% of follicular lymphoma (FL) cases

TRANSLOCATION
SHGC-104619 STSG619400
5' 3'
Gen Tel
BCL2

1.3 mb
NORMAL

RH98285 SHGC-106213
18q21.33 3' 5'
Gen Tel
IGH
14q12.33 TRANSLOCATION
1.5 mb

(Not to scale)

TRANSLOCATION

www.diagen.com.tr References
Baró C, et al. (2011) Leuk Res 35: 256-9.
Da Cunha Santos G, et al. (2011) Cancer Cytopathol 119: 254-62.
Nguyen-Khac F, et al. (2011) Am J Blood Res 1: 13-21.
Bassegio L et al., Br J Haematol 2012;158(4):489-98

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