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Hermatology primeFISH Products
HEMATOLOGY
PANEL
17-180 MLLT4 (6q26.27) Breakapart
The MLLT4 (AFDN) gene encodes a multidomain protein the t(6;11)(q27;q23) translocation. Alternative spliced
involved in cell adhesion signaling and organization transcript variants that encode different isoforms of this
during embryogenesis. It has also been identified as a gene have been identified, but not all of them have been
fusion partner of the acute lymphoblastic leukemia-1 fully characterized.
(ALL-1) gene in acute myeloid leukemias associated with
BREAKAPART
NORMAL
RH37393 SHGC-37128 RH103088 SHGC-145679
3' 5'
Gen Tel
MLLT4(AFDN)
740 kb 369 kb
DELETION
6q27 (Not to scale)
www.diagen.com.tr References
Yang H, Jin L, Sun X, Mol Med Rep. 2019; 19(3):1613-1621
Peterson JF, Baughn LB, Pearce KE, et al. Genes Chromosomes Cancer. 2018; 57(11):541-546
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