Page 34 - DIAGEN-EN

Hematology primeFISH Products

HEMATOLOGY
PANEL

17-075 CSF1R (5q33-34)

Deletion of the CSF1R gene at 5q32 is specifically observed normal breast tissue. Additionally, in cervical cancer, CSF1R
in approximately 40% of patients with Myelodysplastic expression has been demonstrated to be associated with
Syndrome (MDS). Studies have also shown that up to a more aggressive and invasive disease.
58% of all breast carcinomas and 85% of invasive breast
carcinomas express higher levels of CSF1R compared to

DELETION

5p15.31

SHGC-149507 RH13582

Tel Cent
3' 5'
SEMA5A
572 kb NORMAL

D5S1708 RH35759
5' 3'
Cent Tel
CSF1R
DELETION
426 kb

5q32

(Not to scale)

References
www.diagen.com.tr The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Sapi E. Exp Biol Med (Maywood). 2004; 229

(1): 1-11.
Expression of the macrophage colony-stimulating factor and its receptor in gynecologic malignancies. Baiocchi G, Kavanagh J, Talpaz
M, Wharton JT, Gutterman JU, Kurzrock R. Cancer 1991; 67 (4): 990-996
Gu TL, et al. (2007) Blood 110: 323-33.
Wilkinson DG: In Situ Hybridization, A Practical Approach, Oxford University Press (1992) ISBN 0 19 963327 4.

34 PRODUCT CATALOGUE