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Hermatology primeFISH Products

HEMATOLOGY

PANEL

17-075 CSF1R 5q33-34

Deletion of the CSF1R gene at 5q32 is specifically observed normal breast tissue. Additionally, in cervical cancer, CSF1R
in approximately 40% of patients with Myelodysplastic expression has been demonstrated to be associated with
Syndrome (MDS). Studies have also shown that up to a more aggressive and invasive disease.
58% of all breast carcinomas and 85% of invasive breast
carcinomas express higher levels of CSF1R compared to

5p15.31
DELETION

SHGC-149507 RH13582
3' 5'
Tel Gen
SEMA5A
NORMAL
572 kb

D5S1708 RH35759
5' 3'
Gen Tel
CSF1R DELETION
426 kb
5q32

(Not to scale)

References
www.diagen.com.tr The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Sapi E. Exp Biol Med (Maywood). 2004; 229

(1): 1-11.
Expression of the macrophage colony-stimulating factor and its receptor in gynecologic malignancies. Baiocchi G, Kavanagh J, Talpaz
M, Wharton JT, Gutterman JU, Kurzrock R. Cancer 1991; 67 (4): 990-996
Gu TL, et al. (2007) Blood 110: 323-33.
Wilkinson DG: In Situ Hybridization, A Practical Approach, Oxford University Press (1992) ISBN 0 19 963327 4.

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