Page 14 - DIAGEN

Hermatology primeFISH Products

HEMATOLOGY

PANEL

17-033 TEL-AML t(12;21)

t(12;21)(p13.2;q22.1) balanced chromosome transloca- of derivation 21. Detection of t(12;21) by fluorescent in
tion childhood onset B-cell precursor (BCP) is the most situ hybridization (FISH) allows simultaneous detection
common genetic rearrangement in acute lymphoblastic of the most common secondary changes and provides
leukemia (ALL) (19-27% of BCP-ALL) occurs in the early additional infor mation about the likely outcome of the
stages of pregnancy) and has been associated with a disease in ALL patients.
good progno sis. in ETV6/RUNX1 positive ALL, three
secondary abnormalities have been found to impair the
clini cal course: deletion of the second non-translocation
ETV6 allele, gains of the RUNXl gene, and duplication

12p13.2 TRANSLOCATION

SHGC-3144 RH52796
5' 3'
Tel Gen
ETV6
536 kb NORMAL

D21S330 SHGC-110084
3' 5'
Gen Tel
TRANSLOCATION
RUNX1
724 kb
21q22.12

(Not to scale) TRANSLOCATION

www.diagen.com.tr References
Peter A, et al. (2009) Eur J Haematol 83: 420-32.
Wilkinson DG: In Situ Hybridization, A Practical Approach, Oxford University Press (1992) ISBN 0 19 963327 4.
Raynaud et al., Blood 1996;87(7):2891-2899
Sun et al (2017) Oncotarget 8:35445-35459 Sun et al (2017) Oncotarget 8:35445-35459

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