Page 14 - DIAGEN-EN
P. 14
Hematology primeFISH Products
HEMATOLOGY
PANEL
17-033 TEL-AML t(12;21)
t(12;21)(p13.2;q22.1) balanced chromosome of derivation 21. Detection of t(12;21) by fluorescent in
translocation childhood onset B-cell precursor (BCP) is situ hybridization (FISH) allows simultaneous detection
the most common genetic rearrangement in acute of the most common secondary changes and provides
lymphoblastic leukemia (ALL) (19-27% of BCP-ALL) additional infor mation about the likely outcome of the
occurs in the early stages of pregnancy) and has disease in ALL patients.
been associated with a good prognosis. In ETV6/
RUNX1 positive ALL, three secondary abnormalities
have been found to impair the clinical course: deletion
of the second non-translocation ETV6 allele, gains of
the RUNX1 gene, and duplication
TRANSLOCATION
12p13.2
SHGC-3144 RH52796
5' 3'
Tel Cent
ETV6
536 kb
NORMAL
D21S330 SHGC-110084
3' 5'
Cent Tel
RUNX1
724 kb TRANSLOCATION
21q22.12
(Not to scale)
www.diagen.com.tr References
Peter A, et al. (2009) Eur J Haematol 83: 420-32.
Wilkinson DG: In Situ Hybridization, A Practical Approach, Oxford University Press (1992) ISBN 0 19 963327 4.
Raynaud et al., Blood 1996;87(7):2891-2899
Sun et al (2017) Oncotarget 8:35445-35459 Sun et al (2017) Oncotarget 8:35445-35459
14 PRODUCT CATALOGUE
