Page 11 - DIAGEN-EN

primeFISH Products Hematology

HEMATOLOGY
PANEL

17-004 p16 (9p21)

The CDKN2A (cyclin dependent kinase inhibitor 2A) gene, inactivated by homozygous deletions with high frequency
often referred to as p16 or INK4a/ ARF, is located in in various human primary tumors such as bladder and
the 9p21.3 chromosome region. Using alternative first renal cell carcinomas, prostate and ovarian adeno
exons and an alternative reading frame, the gene carcinomas, non-small cell lung cancer, sarcoma,
encodes two different tumor suppressor proteins glioma, mesothelioma, and melanoma. Furthermore,
p161NK4a and p14ARF, both of which are involved in deletion of the CDKN2A gene is found in up to 80% of T-
cell cycle regulation. CDKN2A has been identified as a cell acute lymphoblastic leukemia cases and is associated
major susceptibility gene for melanoma. The tumor with poor prognosis and disease relapse.
suppressor gene CDKN2A is

DELETION

9p21.3

D9S1749 D9S1752
3' 5'
NORMAL
Cent Tel
9q12 CDKN2A

246 kb

DELETION

(Not to scale)

References
Wilkinson DG: In Situ Hybridization, A Practical Approach, Oxford University Press (1992) ISBN 0 19
963327 4. www.diagen.com.tr
Schwarz S, et al. (2008) Cytometry A 73: 305-11.
Quelle DE, et al. (1995) Cell 83: 993-1000.

PRODUCT CATALOGUE 11