Page 6 - DIAGEN-EN

Hematology primeFISH Products

HEMATOLOGY
PANEL

17-040 BCR-ABL t(9;22)

Rearrangements involving t(9;22)(q34.1q11.2) are This translocation often results in a chimeric
observed in approximately 90% of adults with chronic BCR/ ABL1 fusion gene on the derivative 22nd
myeloid leukemia (CML) and approximately 25% of chromosome. The product of this gene is the
adults with acute lymphobalstic leukemia (ALL). The BCR/ ABL1 protein with abnormal tyrosine kinase
presence of a BCR-ABL1 fusion has important diagnostic activity. in normal cells, ABL1 kinase activity is well
and prognostic implications in various hematological regulated in response to growth factors and other
diseases. Rearrangements are characterized stimulant.
cytogenetically by the presence of the Philadelphia (Ph)
chromosome.

TRANSLOCATION

SHGC-104045 RH80328
5' 3'
22q11.22-q11.23 Cent Tel
BCR

1.1 mb
NORMAL
D9S120 RH41777
5' 3'
Cent Tel
ABL1
939 kb TRANSLOCATION
9q34.11-q34.13

(Not to scale)

www.diagen.com.tr References
Hehne S, et al. (2012) Pathol Res Pract 208: 510-7.
Zheng X, et al. (2009) PLoS One 4: e7661.
Mascarello JT, Hirsch B, Kearney HM, et al. Section E9 of the American College of Medical Genetics technical standards and guidelines:
fluorescence in situ hybridization. Genet Med. 2011;13(7):667-675.
Soupir et al., Am J Clin Pathol 2007;127:642-650

6 PRODUCT CATALOGUE