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Hermatology primeFISH Products

HEMATOLOGY

PANEL

17-040 BCR-ABL t(9;22)

Rearrangements involving t(9;22)(q34.l;qll.2) are observed This translocation often results in a chimeric BCR/ ABLl
in approximately 90% of adults with chronic myeloid fusion gene on the derivative 22nd chromosome. The
leukemia (CML) and approximately 25% of adults with product of this gene is the BCR/ ABLl protein with abnor-
acute lymphobalstic leukemia (ALL). The presence ofa mal tyrosine kinase activity. in normal cells, ABLl kinase
BCR-ABLl fusion has important diagnostic and prognostic activity is well regulated in response to growth factors
implications in various hematological diseases. Rearrange and other stimuli.
ments are characterized cytogenetically by the presence
of the Philadelphia (Ph) chro mosome.

AHGC-104045 RH80328 TRANSLOCATION
5' 3'
22q11.22-q11.23 Gen Tel
BCR

1.1 mb
NORMAL
D9S120 RH41777
5' 3'
Gen Tel
ABL1
939 kb TRANSLOCATION
9q34.11-q34.13

(Not to scale)
TRANSLOCATION

www.diagen.com.tr References
Hehne S, et al. (2012) Pathol Res Pract 208: 510-7.
Zheng X, et al. (2009) PLoS One 4: e7661.
Mascarello JT, Hirsch B, Kearney HM, et al. Section E9 of the American College of Medical Genetics technical standards and guidelines:
fluorescence in situ hybridization. Genet Med. 2011;13(7):667-675.
Soupir et al., Am J Clin Pathol 2007;127:642-650

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