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Hematology primeFISH Products

HEMATOLOGY
PANEL

17-001-A del (13q14) (D13S319) /LAMP1 (13q34) / Cent 12

Deletions covering the 13q14 region are frequently Trisomy 12 is another common chromo somal abnormality
seen in a wide range of hematological disorders. seen in CLL and is de tected in approximately 20% of CLL
Chromosome 13q deletions occur in 16-40% of multiple cases. Trisomy 12 is associated with a moderate prognostic
myeloma (MM) cases, and most are completely outcome when there is only one abnormality. Therefore,
monosomy 13 (85%); the remaining 15% constitutes the when used in conjunction with other biomarkers, mor
deletion of 13q14. A case study of patients with phology, and clinical information, FISH is a valuable tool
multiple myeloma narrowed the critically deleted for predicting disease progression and overall survival
region to 13q14. Historically, deletions of 13q have in CLL patients.
been associated with poor prognosis in MM, but its
prognostic relevance is now believed to be related to
its association with other concomitant genetic lesions.
Deletions in the long arm of chromo some 13 are
also frequently detected in patients with aggressive
nonHodgkin lymphoma (NHL).

DELETION

D12Z3 D13S319 D13S1556
(12p11.1-q11.1) 3' 5'
Cent Tel
DLEU2
NORMAL
13q14.2
405 kb

SHGC-110591 RH17637
5' 3'
Cent Tel
DELETION
LAMP1
576 kb
13q34

(Not to scale)

www.diagen.com.tr References
Ouillette P, et al. (2011) Clin Cancer Res 21: 6778-90.
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New
Jersey: John Wiley & Sons Inc.
Nelson et al (2007) Am J Clin Pathol 128:323-332
Doehner et al (2000) N Engl J Med 343:1910-1916

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