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17-001-A del (13q14) (D13S319) /LAMP1 (13q34) / Cent 12

Deletions covering the 13ql4 region are frequently seen Trisomy 12 is another common chromo somal abnormality
in a wide range of hema tological disorders. Chromosome seen in CLL and is de tected in approximately 20% of CLL
13q de letions occur in 16-40% of multiple myelo ma (MM) cases. Trisomy 12 is associated with a moderate prognostic
cases, and most are complete ly monosomy 13 (85%); the outcome when there is only one abnormality. Therefore,
remaining 15% constitutes the deletion of 13ql4. A case when used in conjunction with other biomarkers, mor
study of patients with multiple myeloma narrowed the phology, and clinical information, FISH is a valuable tool
critically deleted region to 13ql4. Historically, deletions far predicting disease pro gression and overall survival
of 13q have been associated with poor prognosis in in CLL pa tients.
MM, but its prognostic relevance is now believed to be
related to its association with other concomitant genetic
lesions. Deletions in the long arm of chromo some 13
are also frequently detected in patients with aggressive
nonHodgkin lymphoma (NHL).

D12Z3 D13S319 D13S1556
(12p11.1-q11.1) 3' 5'

Gen Tel
DLEDU2

13q14.2
405 kb

SHGC-110591 RH17637
5' 3'
Gen Tel
LAMP1
576 kb
13q34

(Not to scale)

www.diagen.com.tr References
Ouillette P, et al. (2011) Clin Cancer Res 21: 6778-90.
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New
Jersey: John Wiley & Sons Inc.
Nelson et al (2007) Am J Clin Pathol 128:323-332
Doehner et al (2000) N Engl J Med 343:1910-1916

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