Page 9 - DIAGEN-EN

primeFISH Products Hematology

HEMATOLOGY
PANEL

17-059 del(20q12-13)

Chromosome 20q deletions can occur in a variety of The 20q deletion is seen in approximately 2% of MDS
myeloid disorders; for example, myelodysplastic cases. Patients with del(20q) base have an
syndromes (MDS), acute myeloid leukemia (AML) and advantageous outcome compared to patients with
myeloproliferative neoplasms (MPNs). in MDS, additional abnormalities such as del(5q), del(7q),
del(20q) as the only cytogenetic abnormality is monosomy 7 and trisomy 8. Most del(20q) patients have
associated with a favorable prognosis, better survival, interstitial deletion between 20q11.2 and 20q13.3.
anda lower risk of conversion to AML. Del(20q) with
additional cytogenetic abnormalities predicts a poor
prognosis.

DELETION

SHGC-100713 D20S110
3' 5'
Cent Tel
PTPRT
NORMAL
20q12 515 kb
20q13.11-q13.12 RH65489 3' 5' SHGC-144461

Cent Tel
MYBL2
20q12 DELETION
364 kb

20q13 DELETION
(Not to scale)

References
Okada M, et al. (2012) Cancer Genet 205: 18-24.
Bacher U, et al. (2014) Br J Haematol 164: 822-33. www.diagen.com.tr
Liu et al., Cancer Genet Cytogenet. 2006 Nov;171(1):9-16
Douet-Gilbert et al (2008) Br J Haematol 143:716-720

PRODUCT CATALOGUE 9