Page 13 - DIAGEN-EN

primeFISH Products Hematology

HEMATOLOGY
PANEL

17-032 AML1-ETO t(8;21)

The t(8;21) balanced chromosomal translocation is found Translocation occurs in 10% to 22% of patients with
in approximately 90% of patients with acute myeloid AML FAB type M2 and in 5% to 10% of AML cases; it is
leukemia (AML). AML is a heterogeneous clonal disorder most common in children and young adults2 and is a
of hematopoietic progenitor cells and is one of the most good prognostic indicator.
common malignant myeloid disorders in adults. Run t-
associated transcription factor 1 gene (RUNX1) and
RUNX1 translocation partner 1 gene (RUNX1T1) are
involved in the transcriptional regulation of genes
during normal hematopoiesis.

TRANSLOCATION

D21S330 SHGC-110084
3' 5'
Cent Tel
RUNX1

724 kb

NORMAL
SHGC-149346 D8S412
3' 5'
8q21.3 Cent Tel
RUNX1T1
403 kb
TRANSLOCATION

21q22.12

(Not to scale)

References
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New
Jersey: John Wiley & Sons Inc. www.diagen.com.tr
Jang et al (2010) Ann Clin Lab Sci 40:80-84
Zhang et al (2002) PNAS 99:3070-3075
Dayyani F, et al. (2008) Blood 111: 4338-47

PRODUCT CATALOGUE 13