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primeFISH Products Hermatology
HEMATOLOGY

PANEL

17-032 AML1-ETO t(8;21)

The t(8;21) balanced chromosomal translocation is found hematopoiesis. Translocation occurs in 10% to 22% of
in approximately 90% of patients with acute myeloid patients with AML FAB type M2 and in 5% to 10% of AML
leukemia (AML). AML is a heterogeneous clonal disorder cases; it is most common in children and young adults2
of hematopoietic progenitor cells and is one of the most and is a good prognostic indicator.
common malignant myeloid disorders in adults. Runt-as-
sociated transcription factor 1 gene (RUNXl) and RUNXl
translocation partner 1 gene (RUNXlTl) are involved in
the transcriptional regulation of genes during normal

TRANSLOCATION
D21S330 SHGC-110084
3' 5'
Gen Tel
RUNX1

724 kb
NORMAL

SHGC-149346 D8S412
3' 5'
8q21.3 Gen Tel
RUNX1T1
TRANSLOCATION
403 kb

21q22.12

(Not to scale) TRANSLOCATION

References
Arsham, MS., Barch, MJ. and Lawce HJ. (eds.) (2017) The AGT Cytogenetics Laboratory Manual. New
Jersey: John Wiley & Sons Inc. www.diagen.com.tr
Jang et al (2010) Ann Clin Lab Sci 40:80-84
Zhang et al (2002) PNAS 99:3070-3075
Dayyani F, et al. (2008) Blood 111: 4338-47

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