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Species Determination Panel
Molecular Genetics Diagnostic Products
SPECIES DETERMINATION

PANEL

ldentification of Bacterial Spe cies

DiaRD-VDE Vancomycin resistant en terococci
RT-PCR Kit
Real-time PCR Kit far vancomycin resis tant enterococci
has been developed far the detection of vancomycin
resistant genes. The kit has been designed to have the
broadest possible detection profile while remaining spe-
cific to the vanA and vanB genes that cause vancomycin
resistance. The primer sequences in this kit have 100%
homology with a wide range of vancomycin-resistant
entero cocci as a result of extensive bioinfor matic analysis.
The widespread use of antibiotics has resulted in shifts
in bacte rial development to overcome existing mecha-
nisms to combat bacterial infec tions. Antibiotics such
as penicillin and erythromycin, which used to have high
activity against many bacterial species and strains, have
become less effective due to the increased resistance of
many bacterial strains. Vancomycin-resistant enterococci
(VRE) tend to multiply rapidly due to the high frequency
and continued use of vancomycin.

Enterococci are a group of gram-positive, round-shaped
bacteria that usually live in the gut, although they can
cause infection anywhere in the body. Vancomycin is a
drug with antibacterial action by forming a complex with
the D-alanyl-D-alanine terminal of the peptidoglycan pre-
cursor to block transglycosylation and transpepti dation
during the synthesis of the celi wall of Gram-positive cocci.

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